- 1962-06-16 2 US army officers killed in Saigon
- 1964-11-01 Vietcong-assault on airport Bien Hoa at Saigon
- 1965-03-30 Vietnam War: A car bomb explodes in front of the U.S. Embassy in Saigon, killing 22 and wounding 183 others.
- 1965-06-17 1st bombing by B-52 (50 km north of Saigon)
- 1968-01-30 Viet Cong and the North Vietnamese launch the Tet offensive against South Vietnames and US forces
1968-02-01 Saigon police chief Nguyễn Ngọc Loan executes Viet Cong officer Nguyễn Văn Lém with a pistol shot to head. The execution is captured by photographer Eddie Adams and becomes an anti-war icon.
- 1975-04-04 USAF transport carrying orphans from Saigon crashes killing 155
1975-04-29 Vietnam War: US begins to evacuate it's citizens from Saigon in Operation Frequent Wind in response to advancing North Vietnamese forces, bringing an end to US involvement in the war
- 1975-04-30 Last US helicopter leaves US embassy grounds, Saigon surrenders
- 1989-09-20 Musical "Miss Saigon," premieres in London
- 1991-04-11 "Miss Saigon" opens at Broadway Theater NYC
- 1997-05-09 1st US ambassador since Saigon fell arrives in Vietnam
- 2002-10-29 Ho Chi Minh City ITC Inferno, a fire destroys a luxurious department store with 1,500 people shopping. Over 60 people died and over 100 are missing. It is the deadliest disaster in Vietnam during peacetime.
- 1951-09-14 Eugene H Trinh, Saigon Vietnam, PhD/astronaut (STS 50)
- 1962-09-17 Dustin Nguyen, Saigon Vietnam, actor (Harry-21 Jump Street)
- 1963-03-16 Phung Vuong, Saigon Vietnam, murderer (FBI Most Wanted List)
- 1964-06-18 Thanh Nguyen, Saigon Vietnam, 141 lbs US weightlifter (Olympics-1996)
- 1969-07-25 Angela Melini, Saigon, Vietnam, playmate (Jun, 1992)
- 1971-08-20 Ke Huy Quan, Saigon Vietnam, actor (Sam-Together We Stand)
- 1971-09-05 Kim Maher, Saigon Vietnam, US softball infielder (Olympics-gold-96)
- 1963-06-11 Quang Duc, Buddhist monk, immolates himself on a street in Saigon