- Jun 17 Mumtaz Mahal dies during childbirth. Her husband, Mughal emperor Shah Jahan I, then spends more than 20 years building her tomb, the Taj Mahal.
- Charles I
King of England
- Mar 16 René Le Bossu, French critic (d. 1680)
- Apr 6 Vincenzo De Grandis, composer
- Apr 8 Cornelis de Heem, painter
- May 4 Mary I Henriette Stuart, daughter of Charles I/queen of England
- Jul 15 Jens Juel, Danish diplomat (d. 1700)