- Jan 4 The New York Stock Exchange opens its first permanent headquarters at 10-12 Broad near Wall Street in New York City.
- Jan 31 Congress passes the 13th Amendment, abolishing slavery in America (passes 121-24)
- Jan 31 General Robert E. Lee named Commander-in-Chief of Confederate Armies during US Civil War
- Feb 4 Robert E. Lee is named general-in-chief of Confederate forces
- Feb 17 Columbia, South Carolina, burns down during American Civil War
- Apr 9 US Civil War: Confederate General Robert E. Lee and 26,765 troops surrender at Appomattox Court House to US Lieutenant General Ulysses S. Grant
- Apr 14 US President Abraham Lincoln is shot by John Wilkes Booth at Ford's Theater in Washington
- Apr 27 Steamboat "SS Sultana" explodes in the Mississippi River, killing up to 1,800 of the 2,427 passengers in the greatest maritime disaster in United States history. Most were paroled Union POWs on their way home.
- Jul 5 US Secret Service begins operating under the Treasury Department
- Nov 26 "Alice in Wonderland" by Lewis Carroll is published in America
Henry Highland Garnet becomes the 1st black minister to preach to the US House of Representatives, he talks about the end of slavery
On February 12, 1865