- Jan 7 Impeachment trial of President Bill Clinton begins in the US Senate.
- Feb 12 US President Bill Clinton acquitted by the Senate in his impeachment trial
- Mar 24 Kosovo War: NATO commences air bombardment against Yugoslavia, marking the first time NATO has attacked a sovereign country.
- Mar 29 The Dow Jones Industrial Average closes at 10006.78 - above the 10,000 mark for the first time ever.
- Apr 7 The World Trade Organisation rules in favor of the United States in its long-running trade dispute with the European Union over bananas
- Apr 20 Columbine High School massacre: Eric Harris and Dylan Klebold kill 13 people and injure 24 others before committing suicide at Columbine High School, Colorado
- May 27 The International Criminal Tribunal for the former Yugoslavia indicts Slobodan Milošević and four others for war crimes and crimes against humanity committed in Kosovo
- Oct 12 The Day of Six Billion: the proclaimed 6 billionth living human in the world is born
All My Children star Susan Lucci finally wins a Daytime Emmy after being nominated 19 times, the longest period of unsuccessful nominations in television history
On May 21, 1999
- Mar 13 Wiktoria Gąsiewska, Polish actress
- Mar 19 Tatum McCann, American actress
- Mar 23 Prince Beltran of Bulgaria
- Jul 20 Princess Alexandra of Hanover, daughter of Princess Caroline of Monaco
- Aug 28 Prince Nikolai of Denmark