- Jan 12 Earthquake occurs in Haiti killing 230,000 and destroying the majority of the capital Port-au-Prince
- Apr 20 The Deepwater Horizon drilling rig explodes, killing 11 and causing the rig to sink, causing a massive oil discharge into the Gulf of Mexico and an environmental diaster
- Aug 19 Operation Iraqi Freedom ends, with the last of the United States brigade combat teams crossing the border to Kuwait
- Oct 13 The 2010 Copiapó mining accident in Copiapó, Chile comes to an end as all 33 miners arrive at the surface after surviving a record 69 days underground.
- Dec 22 Repeal of the "Don't Ask Don't Tell policy", a 17-year-old policy banning homosexuals serving openly in the US military, signed into law by President Barack Obama
In the longest match in tennis history, John Isner of the U.S. defeats Nicolas Mahut of France at Wimbledon after 11 hours, 5 minutes of play over three days
On June 24, 2010