Jan 6 Bernard van Orley, Flemish royal painter of Hungary, dies at about 52
May 27 Margaret Pole, 8th Countess of Salisbury (b. 1473) beheaded for treason in Tower of London by Henry VIII
Jun 26Francisco Pizarro, Spanish conquistador who conquered the Inca Empire is assassinated in Lima by the son of his former companion and later antagonist, Diego Almagro the younger. Almagro is later caught and executed.
Jul 4 Pedro de Alvarado, Spanish occupier, dies at about 56