The Santa María was the largest and the flagship of three ships used by Christopher Columbus' for his first voyage to the "Indies" in 1492.
The other two ships were the Pinta and Niña.
The Santa María ran aground and sunk off the island of Hispaniola (Haiti) and was rediscovered in 2014.
- 1492-08-03 Christopher Columbus sets sail on his first voyage with three ships, Santa María, Pinta and Niña from Palos de la Frontera, Spain for the "Indies"
- 1492-10-25 Christopher Columbus' flagship the Santa María lands at Dominican Republic
- 1492-12-25 Christopher Columbus' flagship the Santa María runs aground and sinks on Hispaniola