- Jan 14 Franchinus Gaffurius, Italian music composer, born in Lodi, Italy (d. 1522)
Isabella I of Castile (1451-1504)
Apr 22 Queen of Castile (1479-1504), patron of Christopher Columbus, who initiated the Spanish Inquisition with husband Ferdinand II of Aragon, born in Madrigal de las Altas Torres, Spain
Christopher Columbus (1451-1506)
Oct 30 Italian explorer and navigator who discovered the "New World" for Spain and initiated European colonization, born in the Republic of Genoa on or just before this date