- Jan 17 Frederick III [Frederick the Wise], Elector of Saxony (1486-25) who protected his subject Martin Luther, born in Torgau, Holy Roman Empire (d. 1525)
- Feb 24 Giovanni Pico della Mirandola, Italian scholar and Renaissance philosopher (Oration on the Dignity of Man), born near Modena (d. 1494)
- Oct 29 Alessandro Achillini, Italian physician and philosopher, born in Bologna, Italy (d. 1512)