- Feb 12 Lorenzo Campeggi(o), archbishop of Bologna/diplomat
- Mar 21 Angela Merici, Italian monastery founder/saint
- May 19 Isabella d'Este, Marquise of Mantua, born in Ferrara, Duchy of Ferrara (d. 1539)
- Sep 8 Ludovico Ariosto, Italian poet (Orlando Furioso), born in Reggio Emilia, Italy (d. 1533)
- Oct 13 Mariotto Albertinelli, Italian painter, born in Florence (d. 1515)