- Jan 6 Martin Agricola [Sohr], German Renaissance composer, cantor, and music theorist, born in Ĺwiebodzin, Bohemian Silesia (now Poland) (d. 1556)
- Feb 18 Chaitanya Mahaprabhu, Bengali saint, inspired Chaitanya movement, born in Navadwip, India (d. 1534)
- Jul 14 Andrea del Sarto, Italian painter (Recollets), born in Florence (d. 1530)
- Aug 23 Siegmund Freiherr von Herberstein, Austrian diplomat, born in Vipava, Slovenia (d. 1566)
- Sep 14 Heinrich Cornelius Agrippa von Nettesheim, German royal astrologer, physician and theologian, born in Cologne, Holy Roman Empire (d. 1535)
- Sep 20 Arthur, Prince of Wales, English crown prince, son of King Henry VII of England, 1st husband of Catherine of Aragon, born in Winchester, England (d. 1502)
- Oct 10 Charles III, Duke of Savoy (1504-53), born in Chazey-sur-Ain, France (d. 1553)
- Nov 13 Johann Eck, German Scholastic theologian and early counter-reformer against Lutheran challenges, born in Egg, Swabia (d. 1543)