- Jan 12 Andreas Alicatus, Italian jurist and humanist, born in Alzate Brianza, Duchy of Milan (d. 1550)
- Mar 4 Francesco de Layolle, Italian Renaissance composer and organist, born in Florence, Republic of Florence (now Italy) (d. c. 1540)
- Mar 6 Jean Luis Vives, Spanish scholar and Renaissance humanist thought of as the father of modern psychology, born in Valencia, Crown of Aragon (d. 1540)
- Apr 4 Ambrosius Blarer, German reformer, born in Konstanz, Germany (d. 1564)
- Apr 11 Marguerite of Navarre, Queen of Navarre, wife of Henry II of Navarre, born in Angoulême, France (d. 1549)
- May 8 Andrea Alciato, Italian lawyer and writer, born in Alzate Brianza, Milan, Italy (d. 1550)
- Jul 2 Elizabeth Tudor, English princess, second daughter and fourth child of Henry VII of England and Elizabeth of York, born in Richmond Palace, Surrey, England (d. 1495)
- Sep 12 Lorenzo II de' Medici, Duke of Urbino, born in Florence, Italy (d. 1519)