- Feb 2 Bona Sforza, queen of Sigismund I of Poland (d. 1557)
- Feb 4 Francois Rabelais, French satirist (Gargantua and Pantagruel), born in La Devinière, Touraine, Kingdom of France (d. 1553)
- Feb 20 Johan Friis, chancellor (Denmark, helped formed Lutheranism)
- Mar 1 Il Bacchiacca [Franceso Ubertini], Italian painter
- Mar 24 Georgius Agricola, German mineralogist (De Re Metallica), born in Glauchau, Saxony (d. 1555)
- Apr 20 John Agricola [Schneider], German theologian, a friend of Martin Luther, born in Eisleben, Germany (d.1566)
- May 25 Jacopo da Pontormo [Carucci], Italian painter (Sepulture of Christ), born in Pontormo, Italy (d. 1557)
Francis I of France
Sep 12 King Francis I of France (1515-47), born in Cognac, France (d. 1547)
- Nov 5 Hans Sachs, German composer, playwright, and shoemaker, born in Nürnberg (d. 1576)
Suleiman the Magnificent
Nov 6 Suleiman the Magnificent, Ottoman Sultan and the longest-reigning sultan of the Ottoman Empire (1530-1566), born in Trabzon, Ottoman Empire (d. 1566)
Suleiman the Magnificent
- Dec 20 Oronce Finé, French mathematician & cartographer, born in Briançon, France (d. 1555)