- Feb 22 Cardinal Rodolfo Pio da Carpi, Italian humanist (d. 1564)
Charles V
Feb 24 Charles V, King of Spain (1516-56) and Holy Roman Emperor (1519-56), born in Ghent, Flanders, Habsburg Netherlands (d. 1558)
- Mar 3 Reginald Pole, English Cardinal/"heretic"
- Apr 12 Joachim Camerarius [Liebhard Kammerer], German classical scholar, born in Bamberg, Germany (d. 1574)
- Apr 23 Alexander Ales [Alesius], Scottish theologian of the school of Augsburg, born in Edinburgh (d. 1565)
- Nov 1 Benvenuto Cellini, Italian sculptor, goldsmith and author (Perseus), born in Florence, Italy (d. 1571)