- Feb 2 René de Birague, French cardinal and chancellor (d. 1583)
- Feb 15 Juliana van Stolberg, Dutch countess, mother of William of Orange and Jan Nassau, born at Stolberg (d. 1580)
- Apr 7 Francis Xavier [Francisco de Jasso], Navarrese Catholic missionary to Far East, co-founder of the Society of Jesus, and saint, born in Javier, Spain (d. 1552)
- Apr 13 Peter Faber, French Jesuit theologian (co-founder of Society of Jesus), born in Villaret, Duchy of Savoy Holy Roman Empire (d. 1546)
- Jul 1 Louis II, King of Hungary and Bohemia (1516-26), born in Buda, Kingdom of Hungary (d. 1526)