- Jan 1 Henry, Duke of Cornwall (d. 1511)
- Jun 18 Bartolommeo Ammanati, Italian sculptor and architect, born in Settignano, Italy (d. 1592)
- Jul 1 Hadrianus Junius [Adriaen de Jonghe], Dutch physician, historian and humanist, born in Hoorn, Netherlands (d. 1575)
- Jul 9 Dorothea of Saxe-Lauenburg, Queen of Denmark and Norway, born in Lauenburg Castle, Germany (d. 1571)
- Jul 30 Giorgio Vasari, Italian painter and art historian (Vasari's Lives), born in Arezzo, Republic of Florence (d. 1574)
- Sep 29 Michael Servetus, Spanish theologian and physician (Christianism Rostituta), born in Villanueva or Tudela, Spain (d. 1553)
- Oct 22 Erasmus Reinhold, German mathematician (calculated planetary table), born in Saalfeld, Electorate of Saxony (d. 1553)
- Nov 14 Janus Secundus, Dutch born new Latin poet (Basia), born in The Hague (d. 1536)