- Feb 14 Domenico Maria Ferrabosco, Italian composer & singer of the Renaissance, born in Bologna (d. 1574)
- Jul 9 John van Hembyze, Flemish Calvinist, born in Ghent, Belgium (d. 1584)
- Jul 20 Gaspar Schetz, Dutch treasurer-general, born in Antwerp (d. 1580)
- Sep 24 Catherine of Saxe-Lauenburg, Queen of Gustav I of Sweden, born in Ratzeburg, Germany (d. 1535)
- Oct 30 Jacques Amyot, French humanist, translator and Abbot of Bellozanne, born in Melun (d. 1593)
- Dec 23 Thomas Smith, English diplomat and scholar (d. 1577)