- Jan 4 Willem Teellinck, Dutch theologist/vicar
- Jan 12 Jan Baptist van Helmont, Flemish chemist, (found boiling point temperature)
- Feb 9 John Meursius [van Meurs], Dutch historian
- Apr 12 François de Bassompierre, marshal of France, born in Haroué, France (d. 1646)
- Jul 13 Arthur Dee, English physician, born in Mortlake, London (d. 1651)
- Jul 25 Valerius Otto, German composer, born in Leipzig (d. after 1612)
- Aug 1 Luís Vélez de Guevara, Spanish writer (El diablo cojuelo), born in Écija, Seville, Spain (d. 1644)
- Aug 18 Charlotte Flandrina van Nassau, daughter of Willem I of Orange
- Aug 24 John Amner, English composer, born in Ely, Cambridgeshire (d. 1641)
- Nov 11 Frans Snyders, Flemish painter of animals, born in Antwerp, Spanish Netherlands (d. 1657)
- Nov 22 Johannes Stalpaert van der Wiele, Dutch lawyer, pastor and lyricist, born in The Hague, Netherlands (d. 1630)
- Dec 9 Martinus de Porres, Peruvian saint (patron of social justice), born in Lima, Viceroyalty of Peru (d. 1639)
- Dec 12 Heinrich Steuccius, German composer, born in Weissenfels, Germany (d. 1645)
- Dec 20 John Fletcher, Jacobean playwright, born in Rye, United Kingdom