- Apr 4 Benjamin Kennicott, English churchman and Hebrew scholar, born in Totnes, Devon (d. 1783)
- Apr 7 Hugh Blair, Scottish preacher and man of letters (d. 1800)
- Apr 14 Emanuele Barbella, Neapolitan composer, born in Naples, Italy (d. 1777)
- Apr 20 David Brainerd, American missionary to the Native Americans, born in Haddam, Connecticut (d. 1747)
- Apr 24 Nathaniel Hone, Irish-born portrait and miniature painter, born in Dublin (d. 1784)
- Apr 26 Esek Hopkins, American Revolutionary War admiral and Commander in Chief of the Continental Navy, born in Scituate, Rhode Island (d. 1802)
- Apr 27 Thomas Lewis, Irish-American surveyor, lawyer, and a pioneer of early Virginia, born in County Donegal, Ireland (d. 1790)