- Sep 2 Esteban EcheverrÃa, Argentine writer (d. 1851)
- Sep 6 Horatio Greenough, American neo-classical sculptor and writer (Form & Function), born in Boston, Massachusetts (d. 1852)
- Sep 7 Samuel Wilberforce, English bishop and one of the greatest public speakers of his day (remembered for his opposition to Darwin's theory of evolution), born in London (d. 1873)
- Sep 18 Robert Cowdin, American politician and Brigadier General (Union Army), born in Jamaica, Vermont (d. 1874)
- Sep 25 Frances Adeline Seward, American First Lady of New York (1839-42) and wife of US Secretary of State William H. Seward, born in Cayuga County, New York (d. 1865)
- Sep 27 George Müller, Prussian Christian evangelist and orphanage builder, born in Kroppenstedt, Kingdom of Prussia (d. 1898)
- Sep 30 Samuel Peter Heintzelman, American Major General (Union Army), born in Manheim, Pennsylvania (d. 1880)