- Sep 2 William Seymour Tyler, American educator and historian (d. 1897)
- Sep 3 Paul Kane, Irish-Canadian painter, born in Mallow, County Cork, Ireland (d. 1871)
- Sep 4 Donald McKay, Canadian-American naval architect (built fastest clipper ships), born in Nova Scotia, Canada (d. 1880)
- Sep 7 Hermann Heinrich Gossen, Prussian economist, born in Düren, Germany (d. 1858)
- Sep 10 Albert G. Blanchard, American Brigadier General (Confederate Army), born in Charlestown, Massachusetts (d. 1891)
- Sep 20 Alpheus Starkey Williams, American Brevet Major General (Union Army), born in Deep River, Connecticut (d. 1878)
- Sep 29 Elizabeth Cleghorn Gaskell, novelist, born in London, England