- Apr 14 Junius Spencer Morgan, American merchant and philanthropist (Metro Museum of Art), born in Holyoke, Massachusetts (d. 1890)
- Apr 17 Henry Washington Benham, American Brevet Major General (Union Army), born in Cheshire, Connecticut (d. 1884)
- Apr 18 James McCune Smith, African-American doctor and abolitionist, born in Manhattan, New York (d. 1865)
- Apr 23 Stephen A. Douglas, American politician, US senator from Illinois (Lincoln-Douglas debates), born in Brandon, Vermont (d. 1861)
- Apr 23 Frédéric Ozanam, French scholar and founder of the Society of Saint Vincent de Paul, born in Milan, Italy (d. 1853)