- Apr 2 Erastus Brigham Bigelow, American inventor of weaving machine, born in West Boylston, Massachusetts (d. 1879)
- Apr 2 Henry L. Benning, American Brigadier General (Confederate Army), born in Columbia County, Georgia (d. 1875)
- Apr 3 Lorenzo Snow, 5th president of the Church of Jesus Christ of Latter-day Saints, born in Mantua, Ohio (d. 1901)
- Apr 4 John Blair Smith Todd, American politician and Brigadier General (Union Army), born in Lexington, Kentucky (d. 1872)
- Apr 15 John Lothrop Motley, American historian and author (The Rise of the Dutch Republic), born in Dorchester, Boston (d. 1877)
- Apr 19 Louis Amédée Achard, French novelist (The Cloak and Dagger), born in Marseille, France (d. 1875)
- Apr 21 Angela Burdett-Coutts, English philanthropist extrordinaire and "the richest heiress in England", born in London (d. 1906)
- Apr 21 Béni Egressy, Hungarian composer, librettist, and actor, born in Kazincbarcika, Hungary (d. 1851)
- Apr 24 Vicente Fidel López, Argentine historian (La Novia del Hereje), born in Buenos Aires, Argentina (d. 1903)