- Apr 1 Johannes J van Oosterzee, Dutch theologist
- Apr 2 Teodulo Mabellini, Italian composer, born in Pistoia, Italy (d. 1897)
- Apr 4 John Wilson Sprague, American Brevet Major General (Union Army), born in White Creek, New York (d. 1893)
- Apr 13 Alphonse Wauters, Belgian historian and archivist (Brussels), born in Brussels, Belgium (d. 1898)
- Apr 18 George Henry Lewes, English philosophical writer (Life of Goethe), born in London (d. 1878)
- Apr 19 John Philip "Spanish John", Scottish painter, born in Aberdeen (d. 1865)