- Jan 11 John Reese Kenly, American Brevet Major General (Union Army), born in Baltimore, Maryland (d. 1891)
- Jan 14 Zacharias Topelius, Finnish historical novelist (Surgeon's Stories), born in Nykarleby, Finland (d. 1898)
- Jan 17 Antoine-Aimé Dorion, Canadian politician and jurist (joint premier of Canada 1858, 1863-64), born in Ste-Anne-de-la-Pérade, Lower Canada (d. 1891)
- Jan 18 Johannes van Vloten, Dutch literary figure and theologist (d. 1883)
- Jan 28 George Sewall Boutwell, MC (Union), (d. 1905)
- Jan 31 William Raine Peck, Brigadier General (Confederate Army), (d. 1871)
- Feb 6 William Maxwell Evarts, American lawyer & statesman (Union), born in Charlestown, Massachusetts (d. 1901)
- Feb 8 Austin Blair, American politician, Governor of Michigan, born in New York (d. 1894)
- Feb 10 Isham Green Harris, Gov (Confederacy), (d. 1897)
Frederick Douglass (c. 1817/18-1895)
Feb 14 African-American abolitionist, lecturer and editor who was also an escaped slave [exact birth year unknown], born in Talbot County, Maryland
- Feb 23 Jeremy Francis Gilmer, American general and engineer (Chief Engineer for Confederate War Dept, planned defense of Atlanta), born in Guilford County, North Carolina (d. 1883)
- Mar 6 William Claflin, 27th Governor of Massachusetts (d. 1905)
- Mar 10 George Wythe Randolph, American Secretary of War for the Confederacy, born in Charlottesville, Virginia (d. 1867)
- Mar 11 John Wilkins Whitfield, American Brigadier General (Confederate Army), born in Franklin, Tennessee (d. 1879)
- Mar 12 John Lorimar Worden, Capt (Union Navy), (d. 1897)
- Mar 13 Albion Parris Howe, American Brevet Major General (Union Army), born in Standish, Maine (d. 1897)
- Mar 15 Mariano Álvarez, Filipino general (d. 1924)
- Mar 22 John Ainsworth Horrocks, English-born explorer of South Australia (d. 1846)
- Mar 23 Don Carlos Buell, American Major General (Union Army), born in Lowell, Ohio (d. 1898)
- Mar 25 Isaac Ingalls Stevens, American Major General (Union Army), born in North Andover, Massachusetts (d. 1862)
- Mar 27 Jacob Axel Josephson, Swedish composer, born in Stockholm, Sweden (d. 1880)
- Mar 28 Wade Hampton, American politician, Lt Gen (Confederate Army), born in Charleston, South Carolina (d. 1902)
- Apr 4 Thomas Mayne Reid, Irish-American novelist (The Headless Horseman), born in Ballyroney, County Down, Ireland (d. 1883)
- Apr 5 Lewis Baldwin Parsons, American Brevet Major General (Union Army), born in Perry, New York (d. 1907)
- Apr 6 Aasmund Olavsson Vinje, Norwegian poet (d. 1870)
- Apr 6 Francis Henry Brown, American teacher and composer (popular pre civil war composer), born in Newburyport, Massachusetts (d. 1891)
- Apr 8 Christian IX, King of Denmark (1863-1906), born in Gottorf Castle, Schleswig, Duchy of Schleswig (d. 1906)
- Apr 14 Marie of Saxe-Altenburg, Queen of Hanover, born in Hildburghausen, Saxe-Hildburghausen (d. 1907)
- Apr 20 Heinrich Göbel, German-born mechanic and inventor, born in Springe, Germany (d. 1893)
- Apr 22 Cadwallader Colden Washburn, American Major General (Union Army), born in Livermore, Maine (d. 1882)
- Apr 23 James Anthony Froude, English historian and novelist (The Nemesis of Faith), born in Dartington Rectory, Devon (d. 1894)
- Apr 23 John Gill Shorter, American politician (17th Governor of Alabama), born in Monticello, Georgia (d. 1872)
- Apr 25 Marek Konrad Sokolowski, Polish guitarist and composer, born in Zhytomyr, Ukraine (d. 1883)
Alexander II (1818-1881)
Apr 29 Tsar of Russia (1855-81), born in the Moscow Kremlin in Russia
- May 1 José Amador de los Ríos, Spanish historian and poet, born in Baena, Spain (d. 1878)
Karl Marx (1818-1883)
May 5 German philosopher (Communist Manifesto, Das Kapital), born in Trier, Prussia
- May 20 William George Fargo, founder (Wells Fargo)
- May 25 Jacob Burckhardt, Swiss cultural historian, born in Basel, Switzerland (d. 1897)
- May 27 Amelia Jenks Bloomer, American reformer who campaigned for temperance and women’s rights, born in Homer, New York (d. 1894)
- May 28 P. G. T. Beauregard, American Confederate general (Hero of Sumter), born in St. Bernard Parish, Louisiana (d. 1893)
- May 31 John Albion Andrew, American politician (25th Governor of Massachusetts), born in Windham, Massachusetts (d. 1867)
- Jun 3 Louis Faidherbe, French general and colonel administrator in Senegal, born in Lille, France (d. 1889)
- Jun 17 Charles Gounod, French opera composer (Faust), born in Paris, France (d. 1893)
- Jun 17 Sophie of Württemberg, Queen of Netherlands as wife of William III, born in Ludwigsburg Palace, Stuttgart, Württemberg (d. 1877)
- Jun 21 Ernst II, Duke of Saxon-Coburg-Gotha (1844-93) and composer, born in Ehrenburg Palace, Coburg, Germany (d. 1893)
- Jun 21 Joseph Abel Haskin, American Brigadier General (Union Army), born in Troy, New York (d. 1874)
- Jun 23 Simon Vissering, Dutch economist/minister of Finances (1879-81)
- Jun 30 Edward John Hopkins, British chorister, organist (Temple Church, 1843-98), and composer, born in Westminster, England (d. 1901)
- Jul 1 Ignaz Semmelweis, Hungarian physician who discovered the cause of puerperal (childbed) fever and introduced antisepsis into medical practice, born in Budapest, Hungary (d. 1865)
- Jul 6 Adolf Anderssen, German World Chess Champion (1851-66), born in Kingdom of Prussia (d. 1879)
- Jul 10 John Stuart Williams, American Brigadier General (Confederate Army), born in Mount Sterling, Kentucky (d. 1898)
- Jul 14 Nathaniel Lyon, American Brigadier General (Union Army), 1st Union General to die in battle, born in Ashford, Connecticut (d. 1861)
- Jul 15 Heinrich Esser, German violinist and composer, born in Mannheim (d. 1872)
- Jul 18 Louis Gerhard De Geer, 1st Swedish Prime Minister (1876-80), born in Finspång Castle, Sweden (d. 1896)
- Jul 24 Félix Godefroid, Belgian harpist and composer, born in Namur, Belgium (d. 1897)
Emily Brontë (1818-1848)
Jul 30 English novelist (Wuthering Heights), born in Thornton, West Yorkshire
- Jul 30 John Heemskerk, Dutch politician (Minister of the Interior 1866-88), born in Amsterdam, Netherlands (d. 1897)
- Jul 31 Heinrich Kiepert, German cartographer/geographer
- Aug 1 Maria Mitchell, 1st US woman astronomer (Vassar), born in Nantucket, Massachusetts (d. 1889)
- Aug 2 Prince Alexander of the Netherlands, Prince of Orange-Nassau, born in Soestdijk, Netherlands (d. 1848)
- Aug 3 Joseph Schadde, Flemish architect (New Stock exchange Antwerp), born in Antwerp (d. 1894)
- Aug 4 Lovell Harrison Rosseau, American lawyer politician and Major General (Union Army), born in Stanford, Kentucky (d. 1869)
- Aug 7 Henry Litolff, French composer and pianist, born in London, England (d. 1891)
- Aug 13 Lucy Stone, American abolitionist (US Woman's Suffrage Association), born in West Brookefield, Massachusetts (d. 1893)
- Aug 18 William Farquhar Barry, American Brevet Major General (Union Army), born in NYC, New York (d. 1879)
- Aug 23 Rufus Ingalls, American Brevet Major General (Union Army), born in Denmark, Maine (d. 1893)
- Aug 30 Alexander H. Rice, American businessman and politician, 30th Governor of Massachusetts (1876-78), born in Newton, Massachusetts (d. 1895)
- Sep 7 Thomas Talbot, American politician, 31st Governor of Massachusetts, born in Cambridge, New York (d. 1885)
Richard Jordan Gatling (1818-1903)
Sep 12 American inventor famous for the Gatling Gun, the 1st hand-cranked machine gun, born in Hertford County, North Carolina
- Sep 13 Gustave Aimard, French world explorer and writer (Grande Flibuste), born in Paris (d. 1883)
- Sep 16 Francis Seymour Haden, English surgeon and etcher, born in London (d. 1910)
- Sep 18 Marcellus Augustus Stovall, American Brigadier General (Confederate Army), born in Sparta, Georgia (d. 1895)
- Oct 4 Francesco Crispi, Italian statesman, born in Ribera, Italy (d. 1901)
- Oct 6 Joseph Rummel, German pianist, and composer, born in Wiesbaden, Hesse, The German Confederation (d. 1880)
- Oct 8 John Henninger Reagan, American Confederate politician, born in Sevier County, Tennessee (d. 1905)
- Oct 15 Irvin McDowell, American Major General (Union Army), born in Columbus, Ohio (d. 1885)
- Oct 15 Johann Gungl, Austrian composer and conductor, born in Zsambék, Austrian Empire (d. 1883) (alternatively born March 5 1828)
- Oct 18 Edward Otho Cresap Ord, American engineer and Major General (Union Army), born in Cumberland, Maryland (d. 1883)
- Oct 22 Leconte de Lisle, French poet and writer, born in Saint-Paul, Réunion, France (d. 1894)
- Oct 25 Pavel Melnikov, Russian historian and author (In the Forests) [NS=Nov 6], born in Nizhny Novgorod, Russian Empire (d. 1883)
- Oct 26 Stefano Golinelli, Italian pianist and composer, born in Bologna, Italy (d. 1891)
- Nov 3 Gustavus Adolphus DeRussy, American Brigadier General (Union Army), born in Brooklyn, New York (d. 1891)
- Nov 4 Alexander Robert Lawton, Brigadier General (Confederate Army), (d. 1896)
Benjamin Butler (1818-1893)
Nov 5 American Major General (Union Army), Governor of Massachusetts (1883-84) and US presidential candidate (Greenback anti-monopoly ticket), born in Deerfield, New Hampshire
- Nov 7 Emil du Bois-Reymond, German physiologist, co-discoverer of nerve action potential and founder of modern electrophysiology, born in Berlin, Germany (d. 1896)
- Nov 9 Ivan Turgenev, Russian novelist, poet and playwright (Fathers & Sons), born in Oryol, Russian Empire (d. 1883)
- Nov 22 Samuel Gibbs French, American Major General (Confederate Army), born in Mullica Hill, New Jersey (d. 1910)
- Nov 26 Louis Lacombe, French pianist and composer, born in Bourges, France (d. 1884)
- Nov 29 George Brown, Birtish-Canadian journalist, publisher (Toronto Globe), Premier of Canada West (Liberal: 1858) and one of the Fathers of Confederation, born in Alloa, Clackmannanshire, Scotland (d. 1880)
- Dec 4 William Wing "Old Blizzards" Loring, American Major General (Confederate Army), born in Wilmington, North Carolina (d. 1886)
- Dec 12 Paul Octave Hébert, American Brigadier General and 14th Governor of Louisiana, born in Plaquemine, Louisiana (d. 1880)
Mary Todd Lincoln (1818-1882)
Dec 13 American wife of Abraham Lincoln and US First Lady (1861-65), born in Lexington, Kentucky
- Dec 21 Amalia of Oldenburg, Queen of Greece, Bavarian born wife of King Otto of Greece, born in Oldenburg (d. 1875)
- Dec 21 Lewis H. Morgan, American ethnologist (Systems of Consanguinity), born in Aurora, New York (d. 1881)
- Dec 23 David Addison Weisiger, Brigadier General (Confederate Army), (d. 1899)
- Dec 24 James Prescott Joule, English physicist (the law of conservation of energy), born in Salford, United Kingdom (d. 1889)
- Dec 30 James Cantey, Brigadier General (Confederate Army), (d. 1874)
- Dec 31 Maria Gartmann, Dutch actress, born in The Hague, Netherlands (d. 1885)