John Singleton Mosby
Dec 6 John S. Mosby, Confederate army cavalry battalion commander in the American Civil War, born in Powhatan County, Virginia (d. 1916)
- Dec 12 Matthias Hohner, German manufacturer (harmonica), born in Trossingen, Germany (d. 1902)
- Dec 17 James T. Holtzclaw, American Brigadier General (Confederate Army), born in McDonough, Georgia (d. 1893)
- Dec 20 Samuel Mudd, American physician (imprisoned for conspiring with John Wilkes Booth), born in Charles Country, Maryland (d. 1883)
- Dec 28 Charles Miller Shelley, Brigadier General (Confederate Army), (d. 1907)
- Dec 29 John James Ingalls, US politician (Rep-Ks), born in Middleton, Massachusetts (d. 1900)