- Sep 6 Breanna Lynn Bartlett-Stewart, first Kleihauer-Betke stillbirth, born in Paragould, Arkansas (d. 2000)
- Sep 7 Ariarne Titmus, Australian swimmer (Olympic gold 200/400m 2021; World C'ship gold 400m, 4x200m 2019), born in Launceston, Australia
- Sep 8 Shane Dylan, American jazz-hip-hop pianist composer, and record producer, born in Boston, Massachusetts
- Sep 9 Victoria Federica de Marichalar y de Borbón, granddaughter of king Juan Carlos I of Spain
- Sep 26 Princess Salma bint Al Abdullah II of Jordan, born in Amman, Jordan
About September 2000
How Old? 22 years old
Generation: Generation Z
Leap Year: Yes