Apr 24Michelangelo undertakes to carve 12 Apostles for the Cathedral of Florence, each four and a quarter braccia high (248.2cm), at the rate of at least one completed statue per year. He produced only one, of St. Matthew, and that remained unfinished.
Apr 28 Battle at Cerignalo: Spanish army under Gonzalo Fernández de Córdoba defeats a French force led by Louis d'Armagnac, Duke of Nemours
Apr 7 [Zoe] Sophia Palaiologina, Byzantine princess, wife of Grand Prince Ivan III of Moscow, dies (b. 1449)