Historical Events
- May 1 First emigrant wagon train leaves Independence, Missouri, for California
- May 3 New Zealand proclaimed a colony independent of New South Wales
Event of Interest
May 11 American Charles Wilkes lands at Fort Nisqually in Puget Sound

Charles Wilkes
Famous Birthdays
- May 10 James Gordon Bennett Jr., American publisher (d. 1918)
- May 11 Ernst von Possart, German actor and theatre director (Bayerische Hoftheater), born in Berlin, Germany (d. 1921)
- May 14 Sir Squire Bancroft [Butterfield], British actor and manager known for creating 'drawing-room comedy' (Haymarket), born in Rotherhithe, London (d. 1926)
- May 15 Giovanni Bolzoni, composer
- May 20 Sara Louisa Oberholtz, social reformer, anti-smoking advocate
- May 21 Joseph Parry, Welsh composer and musician, born in Merthyr Tydfil, Wales (d. 1903)
- May 22 Catulle Mendès, French poet, born in Bordeaux, France (d. 1909)
- May 24 Charles Napier Hemy, British painter, born in Newcastle, England (d. 1917)
- May 24 Tito Mattei, Italian pianist and composer, born in Campobasso, Italy (d. 1914)
- May 28 Giovanni Sgambati, Italian pianist and composer, born in Rome (d. 1914)
- May 29 Sylvester Magee, last living American slave and oldest person who ever lived, born in North Carolina (d. 1971)