- Jan 13 Microsoft chairman Bill Gates steps aside as chief executive and promotes company president Steve Ballmer to the position
- Mar 10 The NASDAQ Composite stock market index peaks at 5132.52, signalling the beginning of the end of the dot-com boom
- May 11 India's population officially reaches 1 billion - Astha Arora named India's billionth baby
- Jun 13 President Kim Dae Jung of South Korea meets Kim Jong-il, leader of North Korea, for the beginning of the first ever inter-Korea summit, in the northern capital of Pyongyang.
- Jun 16 Israel complies with UN Security Council Resolution 425 after 22 years, which calls on Israel to completely withdraw from Lebanon. Israel withdraws from all of Lebanon, except the disputed Sheba Farms
- Nov 7 Controversial US presidential election between George W. Bush and Al Gore is inconclusive; the result, in Bush's favor, is eventually resolved by the Supreme Court
- Dec 12 United States Supreme Court releases its decision in Bush v. Gore
- Apr 7 South African cricket captain Hansie Cronje is charged by Delhi police with fixing One Day International matches against India
- Jul 23 British Open Golf, Royal Lytham & St. Annes: Tiger Woods beats Thomas Bjørn and Ernie Els by 8 shots to win his first Open title; becomes youngest player at 24 to win all 4 major titles
- Aug 20 PGA Championship, Valhalla GC: Tiger Woods becomes first since Ben Hogan (1953) to win 3 majors in a calendar year; wins back-to-back PGA titles in 3-hole playoff with Bob May
- Oct 7 Last ever competitive soccer match at Wembley Stadium, England defeated 1-0 by Germany, last goal scored by Liverpool's Dietmar Hammann. Match is Tony Adams' 60th at Wembley, the record for most appearances at the stadium.
The U.S. Drug Enforcement Administration discovers one of the country's largest LSD labs inside a converted military missile silo in Wamego, Kansas
On November 7, 2000