- 1500 Pedro Álvares Cabral is the first european to discover Brazil, landing near Monte Pascoal, claims it for Portugal
- 1915 1st military use of poison gas (chlorine, by Germany) in WW I
- 1976 Barbara Walters becomes 1st female nightly network news anchor (Today Show)
- 1993 Holocaust Memorial Museum dedicated in Washington D.C.
- 1994 7,000 Tutsi's slaughtered by Hutu in the stadium at Kibuye, Rwanda
- 2006 243 people are injured in pro-democracy protest in Nepal after Nepali security forces open fire on protesters against King Gyanendra.
- 2016 Paris Agreement on climate change signed in New York binding 195 nations to an increase in the global average temperature to less than 2°C above pre-industrial levels and to pursue efforts to limit the increase to 1.5°C
More than $3.3 million is stolen from the First National Bank of Arizona in Tucson in the then largest US bank robbery in history
On April 22, 1981
In Denmark the largest lollipop, weighing 3,011 pounds, made
On April 22, 1994
- 1887 Business magnate Andrew Carnegie (51) weds Louise Whitfield (30) in NYC, New York
- 1939 Actor and naval officer of World War II Douglas Fairbanks Jr (29) weds Huntington Hartford's former wife Mary Lee Hartford
- 1995 "Extra" TV co-host Arthel Neville (32) weds Carolina Panther running back Derrick Lassic (25) at Our Lady of Guadalupe Church
- 2000 NFL football player Emmitt Smith (31) weds Miss Virginia USA beauty queen Patricia Southall (29)
- 2003 "Star Trek: Enterprise" actress Jolene Blalock (28) weds "Live Nation" CEO Michael Rapino in Negril, Jamaica