- 334 BC The Macedonian army of Alexander the Great defeats Darius III of Persia in the Battle of the Granicus
- 1570 1st atlas 'Theatrum Orbis Terrarum' (Theatre of the World), published by Abraham Ortelius in Antwerp with 70 maps
- 1843 1st wagon train with 700 - 1000 migrants, departs Independence, Missouri for Oregon
- 1939 Adolf Hitler and Benito Mussolini sign "Pact of Steel" in Berlin, Germany
- 1946 First US rocket (WAC Corporal) to reach edge of space fired from White Sands Missile Range New Mexico
- 2014 Royal Thai Armed Forces, led by General Prayut Chan-o-cha stage a coup in Thailand, suspending the kingdom's constitution and taking control of the government, the 12th since the country's first coup in 1932
The U.S. town of Hallam, Nebraska, is wiped out by a powerful F4 tornado that broke a width record at an astounding 2.5 miles wide. It also kills one local resident.
On May 22, 2004
First modern sighting of the Loch Ness Monster by Aldie and John Mackay saw "something resembling a whale"
On May 22, 1933
- 1860 Major General George McClellan (33) weds Mary Ellen at Calvary Church in NYC, New York
- 1945 Paranormal investigator Lorraine Warren (18) weds partner Ed Warren (18)
- 1956 Actress Anita Ekberg (24) weds actor and singer Anthony Steel (36) in Florence, Italy
- 1980 Actress Marlo Thomas & talk host Phil Donahue marry
- 2003 Actor and comedian Kevin Hart (23) weds Torrei Hart