- Jan 2 Svante, Regent of Sweden (b. 1460)
- Feb 2 Hatüey, Taíno chief known as Cuba's First National Hero, is burned alive by Spanish colonialists
Amerigo Vespucci
Feb 22 Amerigo Vespucci, Italian explorer (America), dies at 60
Amerigo Vespucci
- Apr 3 Richard Pafraet, Dutch printer, dies
- Apr 11 Gaston de Foix, French pretender to Navarra throne, dies in battle
- May 21 Pandolfo Petrucci, Italian ruler of the Republic of Siena (1500-12) during the Renaissance, dies at 60
- May 26 Bayezid II, Ottoman Sultan (1481-1512) dies at 62
- Aug 2 Alessandro Achillini, Italian physician and philosopher, dies at 48
- Oct 15 Antoon Keldermans, Flem builder (Middelburg town hall), dies at 72
- Nov 16 Gerbrand Mockema, Fries rebel, beheaded
- Nov 16 Jemme Herjuwsma, Fries rebel, beheaded
- Nov 17 Kempo Roeper, Frisian rebel, quartered