- Apr 18 Francois Lambert d'avignon, French church reformer, dies at ~43
- Apr 24 Jacopo Sannazaro, Italian poet (De partu Virginis), dies at 74
- Aug 3 Philibert Chalon, prince of Orange/viceroy of Naples, dies
- Sep 29 Andrea del Sato [d'Agnolo di Franceszo], Italian painter, dies at 44
- Nov 29 Thomas Wolsey, Cardinal, adviser and Lord Chancellor, (1515-29) to England's King Henry VIII, dies just before facing treason trial at about 55
- Dec 1 Margaretha of Austria, governess of the Netherlands, dies at 51
Babur (1483-1530)
Dec 26 Timurid founder and 1st Emperor of the Mughal dynasty in the Indian Subcontinent (1526-30), dies at 47
