- Jan 6 Baldassare Peruzzi, Italian architect and painter, dies at 54
Catherine of Aragon (1485-1536)
Jan 7 1st wife of England's King Henry VIII (mother of Mary I), dies at 50
- Jan 22 Bernhard Knipperdolling, German religious leader (b. 1495)
- Feb 3 Garcia de Resende, Port writer/publisher (Cancioneiro Geral), dies
- Feb 25 Berthold Haller, German-born reformer (b. 1492)
- Mar 16 Ibrahim Pasha, grand-visier of Osmaanse Rich, murdered at about 45
- Apr 4 Frederick I, Margrave of Brandenburg-Ansbach (1486-1536), dies at 75
- May 17 George Boleyn, 2nd Viscount Rochford, English brother of Anna Boleyn, beheaded after being tried and convicted for high treason and incest at 32
Anne Boleyn (1501/1507-1536)
May 19 Queen of England (1533-36), second wife of Henry VIII, beheaded at the Tower of London on charges of adultery, incest and treason, at between age 28 to 35
Erasmus (1466-1536)
Jul 12 Dutch humanist and theologian (The Praise of Folly), dies at 69