- Feb 12 Albrecht Altdorfer, German painter, dies at about 57
- Feb 16 Everhard/Erardus van de Mark, prince-bishop of Liege, dies at 65
- Feb 26 Worp van Thabor, Frisian abbott of Thabor (Chronicon Frisiae), dies
- Mar 21 Hugo, earl of Leisnig, governor of Frisia, dies at about 79
- May 8 Edward Fox, English bishop
- May 22 John Forrest, English Franciscan friar (martyred) (b. 1471)
- Jun 30 Charles of Egmond, Duke of Guelder and Earl of Zutphen, dies at 70
Diego de Almagro (1475-1538)
Jul 8 Spanish conquistador of Chile and Peru, executed at Las Salinas at about 63
