- Jan 9 Amago Haruhisa, Japanese samurai and warlord, dies at 46
- Oct 9 Gabriel Fallopius [Fallopio], Italian anatomist and early advocate for the use of condoms (Observationes anatomicae), dies at 39
- Nov 17 Antoine de Bourbon, King of Navarre (1555-62), father of Henry IV of France, dies at 44
- Dec 6 Jan van Scorel, Dutch painter and architect, dies at 67
- Dec 17 Adrian Willaert, Flemish singer, bandmaster, and composer, dies at about 82