- Jan 9 Amago Haruhisa, Japanese samurai and warlord, dies at 46
- Oct 9 Gabriel Fallopius [Fallopio], Italian anatomist and early advocate for the use of condoms (Observationes anatomicae), dies at 39
- Nov 17 Antoine de Bourbon, King of Navarre and father of Henry IV of France (b. 1518)
- Nov 17 Antoine of Navarre [de Bourbon], King of Navarre, 1555-62), dies at 44
- Dec 6 Jan van Scorel, Dutch painter and architect, dies at 67
- Dec 17 Adrian Willaert, Flemish singer/bandmaster/composer, dies at about 82