Albert of Prussia (1490-1568)
Mar 20 1st Duke of Prussia, dies at 77
- May 23 Adolf van Nassau, German son of William I and Juliana of Stolberg, dies in battle at 27
- Jun 1 18 nobles beheaded in Brussels for treason and heresy by Duke of Alva and authority of Council of Troubles
- Jun 1 Gijsbert van Bronkhorst-Batenburg, calvinist leader, beheaded
- Jun 3 Andrés de Urdaneta, Spanish Augustinian friar, and explorer (solved puzzle of Pacific Winds making settlement of Philippines possible), dies at 59 [exact birthdate uncertain, late 1507 - early 1508)
- Jun 5 Lamoral, Count of Egmont, Flemish general and statesman executed at 45
- Jun 5 Philips van Montmorency count of Horne, admiral/statesman, beheaded
- Jun 5 Willem Key, Flemish Renaissance painter, dies at about 47
- Jul 2 Don Carlos, Prince of Asturias, son of Spanish King Philip II, dies after a year of imprisonment by his father for being mentally unstable at about 23
- Jul 6 Johann Oporinus, Swiss book publisher/publisher, dies at 61
- Sep 24 Antoon van Stralen, Flemish mayor of Antwerp, beheaded at about 47
- Oct 3 Elisabeth of Valois, daughter of King Henry II of France and 3rd wife of Philip II of Spain, dies in childbirth at 23
- Oct 14 Jacques Arcadelt, Flemish composer
- Oct 28 Ashikaga Yoshihide, Japanese shogun (b. 1539)
- Dec 23 Roger Ascham, tutor of Elizabeth I of England
- Dec 31 Shimazu Tadayoshi, Japanese warlord, dies at 75