- Feb 19 Orazio Tiberio Vecchi, Italian composer, dies at 54
- Mar 5 Clement VIII [Ippolito Aldofireini], Pope (1592-1605), dies at 69
- Mar 17 Pieter Bast [Bastius], Dutch engraver/cartographer, dies at about 34
- Apr 5 Adam Loftus, English Protestant archbishop in Ireland (c.1513)
- Apr 6 John Stow, English historian (Survey of London), dies
- Apr 23 Boris Godunov, chief adviser to Tsar Fyodor I and Tsar of Russia (1598-1605), dies after a lengthy illness and a stroke at approximately 20
- Apr 25 Naresuan, King of Siam (b. 1555)
- Apr 27 Leo XI, Italian Pope (1605), dies at 69
- May 4 Ulisse Aldrovandi, Italian biologist and naturalist, dies at 82
- Sep 14 Jan Tarnowski, Archbishop of Krakow (b. 1550)
- Sep 23 Pontus de Tyard, French poet
- Sep 24 Manuel Mendes, Portuguese composer and teacher of the Renaissance, dies at about 58
- Oct 13 Theodore Beza, French Reformed Protestant theologian, dies at 86
- Nov 8 Robert Catesby, English conspirator (b. 1573)