- Apr 5 Adam Loftus, English Protestant archbishop in Ireland (c.1513)
- Apr 6 John Stow, English historian (Survey of London), dies
- Apr 23 Boris Godunov, chief adviser to Tsar Fyodor I and Tsar of Russia (1598-1605), dies after a lengthy illness and a stroke at approximately 20
- Apr 25 Naresuan, King of Siam (b. 1555)
- Apr 27 Leo XI, Italian Pope (1605), dies at 69