- Feb 8 Jan H Van Linschoten, traveller/writer (Reys-Gheschrift), dies
- Mar 5 Shimazu Yoshihisa, Japanese warlord and samurai (b. 1533)
- Apr 1 Gillis van Valkenborch, Flemish painter, buried at about 72
- Apr 23 Martin Ruland the Younger, German physician and alchemist, dies at 41
- Jun 8 Jean Bertaut, French poet (b. 1552)
- Jul 26 Horio Yoshiharu, Japanese warlord (b. 1542)
- Aug 2 Kato Kiyomasa, Japanese warlord and samurai (b. 1562)
- Aug 27 Tomés L de Victoria, Spanish composer, singer, organist, and priest, dies at about 53
- Oct 3 Charles, Duke of Mayenne, French military leader, dies at 57
- Oct 30 Charles IX [Carl], King of Sweden (1604-11), dies at 61