- Jan 23 William Baffin, English explorer, dies of a gunshot wound at in attack on Qeshm about 38
- Feb 11 Alfonso Fontanelli, Italian composer (Ferrara School), dies at 64
- Feb 19 Sir Henry Savile, English scholar and educator, translated the New Testament into English, dies at 72
- Mar 5 Ranuccio I Farnese, Duke of Parma and Piacenza (1592-1622), dies at 52
- Apr 24 Fidelis of Sigmaringen, Swiss friar, martyr, and saint, dies at 44
- May 3 Pedro Páez, Spanish Jesuit missionary (b. 1564)
- May 15 Peter Plancius, Flemish vicar/cartographer, dies at about 69
- May 20 Osman II, Sultan of the Ottoman Empire (1618-22), dies at 17
- Jun 16 Alexander Seton, 1st Earl of Dunfermline, Chancellor of Scotland (b. 1555)
- Jul 1 William Parker, 4th Baron Monteagle, English peer and politician who helped stop the Gunpowder Plot, dies at around 47
- Dec 13 Jan Campanus, Czech composer, dies at 50
- Dec 28 Francois de Sales, French bishop of Geneva, writer and saint, dies at 55