- Jan 31 Joost Bürgi, Swiss clockmaker and mathematician (b. 1552)
- Apr 15 George Calvert, Proprietor of the Avalon (Maryland) Colony (b. 1580)
- Apr 20 Nicolas Antione, converted to Judiasm, burned at the stake
- Apr 30 Johann Tserclaes, Count of Tilly, Holy Roman field marshal who commanded the Catholic League's forces in the Thirty Years' War, dies of tetanus after being wounded by a cannonball at 73
Sigismund III Vasa
Apr 30 Sigismund III Vasa, King of Poland and Grand Duke of Lithuania (1587-1632) and King of Sweden (1592-99), dies at 65
- May 25 Adam Tanner, Austrian mathematician and philosopher (b. 1572)
- Jun 2 Ernst Casimir, count of Nassau-Dietz/mayor of Friesland, dies at 58
- Jun 22 James Whitelocke, English judge (b. 1570)
- Jul 29 Samuel Ampzing, vicar/poet (Biblical Treasures), dies
- Aug 20 Valentin de Boulogne, French painter, buried at 38
- Aug 25 Thomas Dekker, English dramatist (b. ca. 1572)
- Sep 13 Leopold V, Archduke of Austria, dies at 45
- Sep 17 Susenyos I, Emperor of Ethiopia (1606-1632), dies at around 60
- Oct 12 Kutsuki Mototsuna, Japanese samurai commander (b. 1549)
- Oct 30 Henri de Montmorency, French duke/plotter, beheaded
- Nov 6 Gustavus II Adolphus, King of Sweden, dies at battle of Lutzen at 37
- Nov 17 Gottfried Heinrich Graf zu Pappenheim, Bavarian field marshal (b. 1594)
- Nov 27 John Eliot, English parliament leader, dies at 40
- Nov 29 Frederick V, Elector Palatine and King of Bohemia, dies at 36
- Dec 8 Philippe van Lansberge, Dutch astronomer, dies at 71
- Dec 20 Nicolas Antoine, French cath pastor who converted to Judaism, executed