- Apr 15 George Calvert, English politician & coloniser, dies at 52
- Apr 20 Nicolas Antoine, French Protestant theologian who attempted to convert to Judaism, burned at the stake for heresy aged about 30 in Geneva, Switzerland
- Apr 30 Johann Tserclaes, Count of Tilly, Holy Roman field marshal who commanded the Catholic League's forces in the Thirty Years' War, dies of tetanus after being wounded by a cannonball at 73
Sigismund III Vasa
Apr 30 Sigismund III Vasa, King of Poland and Grand Duke of Lithuania (1587-1632) and King of Sweden (1592-99), dies at 65
