- Jul 22 Trijntje Keever, presumed to have been the tallest woman ever (b.1616)
- Aug 4 George Abbott, English theologist and the Archbishop of Canterbury (1611-1633), dies at 60
- Aug 12 Jacopo Peri, Italian composer and singer who wrote the 1st recognized opera "Dafne", dies at 71
- Sep 8 Carlo Caraffa, Italian jesuit/religious order founder, dies at about 72
- Oct 1 Filaret [Fjodor N Romanov], patriarch of Moscow, dies
- Oct 26 Horio Tadaharu, Japanese warlord (b. 1596)
- Nov 7 Cornelis Drebbel, physicist/chemist/inventor (builder of the first submarine), dies
- Nov 14 William Ames, English philosopher (b. 1576)
- Dec 1 Isabella Clara Eugenia, Sovereign of the Netherlands (1598-1621), dies at 67
- Dec 18 Theodoor Galle, Flemish engraver, buried at 62