- Jan 6 Elias Hill, German architect of Augsburg, dies at 72
- Mar 20 Matthew Vossius, historian (Annales Holland Zelandiaeque), dies at 35
- Apr 10 Santino Solari, Swiss architect and sculptor (b. 1576)
- Aug 19 Alexander Henderson, Scottish theologian
- Aug 28 Fulvio Testi, Italian poet (Poesie liriche), dies at 53
- Sep 11 Johann Stobaeus, composer, dies at 66
- Sep 14 Robert Devereux, 3rd earl of Essex, dies
- Sep 14 Thomas H Earl of Arundel, English art collector (Marbles), dies
- Sep 24 Duarte Lobo, Portuguese composer (bc. 1565)
- Oct 3 Virgilio Mazzocchi, composer, dies at 49
- Oct 9 Baltasar Carlos, son of Spanish King Philip IV, dies of smallpox at 16
- Oct 12 François de Bassompierre, marshal of France, dies at 67
- Oct 18 Isaac Jogues, French Jesuit missionary (b. 1607)
- Oct 28 William Dobson, English portrait painter, dies at about 35 (b. 1610)
- Nov 29 Laurentius Paulinus Gothus, Swedish theologian and astronomer, dies at 81
- Nov 30 John C Lichthart, admiral (Cape Augustine), dies at about 45
- Dec 22 Peter Mogila, Orthodox Metropolitan of Kiev and Galicia (b. 1596)
- Dec 23 François Maynard, French poet (b. 1582)