- Feb 2 Antonio Maria Valsalva, Italian anatomist (anatomy of the ear), dies at 66
Christopher Wren (1632-1723)
Feb 25 English astronomer and architect (St. Paul's Cathedral), dies at 90
- Feb 26 Thomas d'Urfey, English songwriter and playwright who helped evolve ballad opera, dies at around 69-70
- Mar 15 Johann C. Gunther, German poet, dies at 27
- Mar 31 Edward Hyde, 3rd Earl of Clarendon, British Governor of New York and New Jersey, dies at 61
- Apr 5 J Fischer von Erlach, Austrian architect (Hofburg, Vienna), dies at 66
- Apr 11 John Robinson, English diplomat and prelate, dies at 72
- May 11 Jean Galbert de Campistron, French dramatist, dies at 66
- Jun 7 Miguel Lopez, Spanish composer and organist, dies at 64
- Jul 1 Willem van de Pose, Governor of Cape Colony (1699-1797), dies at about 59
- Jul 14 Claude Fleury, French priest and historian, dies at 82
- Jul 26 Robert Bertie, 1st Duke of Ancaster and Kesteven, English statesman
- Jul 28 Mariana Alcoforado, Portuguese nun, dies at 63
- Aug 10 Guillaume Dubois, French cardinal and statesman, dies at 66
- Aug 17 Joseph Bingham, English scholar (b. 1668)
- Aug 21 Dimitrie Cantemir, Romanian historian and Monarch of Moldova (1710-11), dies at 49
- Aug 23 Antoine Mouque, Flemish composer, organist and singer, dies at 64
- Aug 23 Increase Mather, New England Puritan minister, dies at 84
- Aug 26 Antonie van Leeuwenhoek, Dutch microscopist who was the first to observe bacteria and protozoa and naturalist (Philosophical Transactions), dies at 90
- Oct 10 William Cowper, 1st Earl Cowper, Lord Chancellor of England (b. 1665)
- Oct 31 Cosimo III de' Medici, Grand Duke of Tuscany, monarch of Florence (1670-1723), dies at 81
- Nov 7 Godfrey Kneller, English painter (74-77), dies
- Nov 19 Antoine Nompar de Caumont, French courtier and soldier (b. 1632)
- Dec 1 Susanna Centlivre, English actress known as "the most successful female playwright of the eighteenth century", dies at 66 (approximately)
- Dec 2 Philippe II, Duke of Orléans and Regent of France (1715-23), dies at 49
- Dec 7 Jan Santini Aichel, Bohemian architect (b. 1677)
- Dec 20 Augustus Quirinus Rivinus, German physician and botanist, dies at 71
- Dec 22 Jacques Basnage, French/Dutch historian/vicar, dies at 70