- Oct 10 Pierre-Louis Couperin, French organist and composer, dies at 34
- Oct 15 John Morgan, American physician-in-chief of Continental Army and co-founder of the Medical College at the University of Pennsylvania, the first medical school in Colonial America, dies at 54
- Oct 24 Joaquín Martínez de Oxinagas, composer, dies at 69
- Oct 24 Lucretia Wilhelmina van Merken, Dutch poet, dies at 68
- Oct 27 John Cook, American farmer and Governor of Delaware (b. 1730)