Joseph Priestley
Feb 6 Joseph Priestley, English chemist, theologian and author who discovered oxygen and carbonated water, dies at 70

Joseph Priestley
Immanuel Kant
Feb 12 Immanuel Kant, German philosopher (Zum ewigen Frieden), dies at 79

Immanuel Kant
- Mar 1 Wolfgang Nicolaus Haueisen, German composer, dies at 63
- Mar 4 Karl Leopold Rollig, composer, dies
- Mar 16 Francisco marquis Albergati Capacelli, Italian playwright, dies at 75
- Mar 20 Ignaz Malzat, composer, dies at 47
- Mar 21 Louis-Antoine-Henri de Bourbon-Condé, duc d'Enghien (executed) (b. 1772)
- Mar 30 Victor-François, 2nd duc de Broglie, Marshal of France (b. 1718)
- Apr 3 Jędrzej Kitowicz, Polish priest (b. 1727/1728)
Jacques Necker
Apr 9 Jacques Necker, French finance minister of Louis XVI whose decisions contributed to the outbreak of the French Revolution, dies at 71

Jacques Necker
Alexander Hamilton
Jul 12 Alexander Hamilton, US Founding Father and 1st Secretary of the Treasury (1789-95), killed by Vice President Aaron Burr in pistol duel near Weehawken at 49

Alexander Hamilton
- Jul 17 Christian Ernst Graf, Dutch composer, dies at 80
- Jul 25 William Forsyth, English gardening expert (Forsythia), dies
- Aug 17 Barbara Heck, Irish born North American colonist, organized 1st Methodist church in US in NY, dies (b. 1734)
- Aug 20 Charles Floyd, only fatality of the Lewis and Clark Expedition
- Sep 4 Richard Somers, American naval officer
- Sep 29 Michael Hillegas, first Treasurer of the United States (b. 1728)
- Oct 2 Nicolas-Joseph Cugnot, French inventor who designed & built 1st automobile, dies at 79
- Oct 29 George Morland, English artist of rural landscapes, dies at 41
- Nov 2 Armand-Gaston Camus, French revolutionist and Chairman of the Council of 500, dies at 64
- Nov 5 Elizabeth "Betje" Wolff-Bekker, poetess (Sara Burgerhart), dies at 66
- Nov 14 Aagje Deken, Dutch literary (Sara Burgerhart), dies at 62
- Nov 19 Pietro Alessandro Guglielmi, Italian opera composer, dies at 75
- Nov 23 Richard Graves, English writer, dies at 89
- Dec 19 Mary Bright, British PM Rockingham, dies