- Jan 6 Fanny Burney, English novelist (Camille, Evalina), dies at 87
- Jan 10 Princess Elizabeth of the United Kingdom, 7th child and 3rd daughter of King George III and Charlotte of Mecklenburg-Strelitz, dies at 69
- Jan 22 Johann Friedrich Blumenbach, German anthropologist (b. 1752)
- Feb 18 Jeffry Wyatville, English architect and garden designer (alterations and extensions to Chatsworth House and Windsor Castle), dies at 73
- Mar 2 Wilhelm Olbers, German astronomer and physician who discovered asteroids (Pallas & Vesta), dies at 81
- Mar 12 Friedrich Westenholz, German composer, dies at 61
- Mar 22 Étienne Bobillier, French mathematician, dies at 41
- Mar 23 William Maclure, Scottish-American Geologist (first geological map), dies at 76
- Mar 28 Simon-Antoine-Jean Lhuillier, Swiss mathematician, dies at 89
- Mar 30 George (Beau) Brummell, Dandy, dies
- Apr 17 Hannah Webster Foster, American author (The Coquette; or, The History of Eliza Wharton), dies at 81
- Apr 19 Jean-Jacques Lartigue, Roman catholic bishop of Montreal (b. 1777)
- Apr 25 Siméon-Denis Poisson, French mathematician (Poisson distribution) and physicist, dies at 58
- May 5 Gottlob Benedikt Bierey, German composer, dies at 67
- May 5 Matthäus Fischer, German organist and composer, dies at 76
- May 6 Francisco de Paula Santander, Colombian president and independence leader (b. 1792)
- May 7 Caspar David Friedrich, German painter (b. 1774)
- May 26 Sidney Smith, British admiral, dies at 75
- May 27 Niccolo Paganini, Italian composer and violin virtuoso (Princess Lucca), dies at 57
- May 30 Dominique J de Eerens, gov-gen of Dutch-Indies, dies at 59
- Jun 6 Marcellin Champagnat, French priest (b. 1789)
- Jun 7 Frederik Willem III, King of Prussia (1797-1840), dies at 69
- Jun 19 John Cockerill, English-Belgian industrialist (founded iron, steel, and manufacturing company - John Cockerill & Company), dies at 50
- Jun 25 Leopold count of Limburg Stirum, Dutch general and politician, dies at 82
- Jun 29 Lucien Bonaparte, prince of Canino/Musignano, dies at 65
Karl Ferdinand von Graefe
Jul 4 Karl Ferdinand von Graefe, German surgeon who helped create modern plastic surgery dies at 53
Karl Ferdinand von Graefe
- Jul 21 Moses Waddel, American educator, minister and bestselling author (Memoirs of the Life of Miss Caroline Elizabeth Smelt), dies at 70
- Jul 22 Józef Javurek, Polish-Russian composer, dies at 83
- Jul 23 František Max Kníže, Czech composer, dies at 55
- Aug 18 Antony CW Staring, Dutch patriot/poet (Jaromir), dies at 73
- Aug 24 Joseph Waast Aubert Nonot, composer, dies at 89
- Aug 25 Karl Leberecht Immermann, German writer, dies at 44
- Aug 27 William Kneass, 3rd US chief engraver (1824-40), dies in office
- Sep 8 John H van de Palm, theologist/literature/speaker, dies at 77
- Sep 11 Johannes Hendricus van der Palm, Dutch theologist and Minister of Education, dies at 77
- Sep 15 Franz Pecháček, Austrian-German composer, dies at 47
- Sep 22 Princess Augusta Sophia of the United Kingdom, 6th child and second daughter of King George III and Queen Charlotte, dies at 71
- Sep 25 Jacques-Etienne-Joseph-Alexandre Macdonald, Duc de Tarente, soldier
- Oct 6 François Budan de Boislaurent, French mathematician, dies at 80
- Nov 24 Cornelis RT Krayenhoff, fortress architect/cartographer, dies at 82
- Dec 11 Emperor Kokaku of Japan (b. 1771)